• H&R Moderators: VerbalTruist | cdin | Lil'LinaptkSix

Mixing 5htp with melatonin?

Yeah. Since melatonin is made from serotonin (which is made from 5HTP), it might be like you took a higher dose of melatonin (that is, you feel more tired the next day). I do not know if melatonin is made on an as-needed basis or whenever humans make it. I do not think this has been studied. In any case, it is not like you will get serotonin syndrome or any severe effects like that from combining these (except possibly from extreme doses of 5HTP, but I do not think anyone has ever tried that). But if you do feel tired the next day, get headaches, or any other side effects, try reducing your dose of melatonin.
 
I use this mix all the time with no negative results. In fact a herbal sleeping aid I sometimes use combines the two.
 
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